GRK2抗体;GRK2 Polyclonal Antibod

Description The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytes References 1. Mol Biol Cell. 2008 Jul;19(7):2973-83. 2. Biochemistry. 2009 May 26;48(20):4285-93. Specification Aliases:GRK2; BARK1; FLJ16718; BETA-ARK1; ADRBK1 Entrez GeneID:156 Swissprot:P25098 clone:3F8 WB Predicted band size:80kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human,Mouse,Rat,Monkey Immunogen:Purified recombinant fragment of human GRK2 expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application WB:1/500 - 1/2000 IHC:1/200 - 1/1000 ICC:1/200 - 1/1000 ELISA:1/10000