GNRHR抗体;GNRHR Polyclonal Antib

Description This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. Specification Aliases:HH7, GRHR, LRHR, LHRHR, GNRHR1 Swissprot:P30968 WB Predicted band size:28 kDa Host/Isotype:Rabbit IgG Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human, Mouse Immunogen:Synthetic peptide of human GNRHR Formulation:pH7.4 PBS, 0.05% NaN3, 40% Glycerol Application WB:1/500-1/2000 ELISA:1/1000-1/5000