GRM1抗体;GRM1 Polyclonal Antibod

Description This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. References 1.Breast Cancer Res Treat. 2015 May;151(1):57-73. 2.PLoS One. 2013 Jul 26;8(7):e69851. Specification Aliases:MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85 Entrez GeneID:2911 Swissprot:Q13255  clone:5E12D8 WB Predicted band size:132.4kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human GRM1 (AA: extra 387-486) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application ELISA:1/10000