KPNA2抗体;KPNA2 Polyclonal Antib

Description The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. References 1.Mod Pathol. 2014 Jan;27(1):96-106. 2.PLoS One. 2013;8(3):e57911. Specification Aliases:QIP2; RCH1; IPOA1; SRP1alpha Entrez GeneID:3838 Swissprot:P52292 clone:1E8B7 WB Predicted band size:58kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human,Mouse Immunogen:Purified recombinant fragment of human KPNA2 (AA: 1-530) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application WB:1/500 - 1/2000 IHC:1/200 - 1/1000 ICC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000