HLA-DPB1抗体;HLA-DPB1 Polyclonal

Description HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. References Immunogenetics. 2021 Jun;73(3):253-261.Am J Hum Genet. 2020 Feb 6;106(2):264-271. Specification Aliases:DPB1; HLA-DP; HLA-DPB; HLA-DP1B Entrez GeneID:3115 Swissprot:P04440 clone:5C9F4 WB Predicted band size:29.2kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human, Rat Immunogen:Purified recombinant fragment of human HLA-DPB1 (AA: extra 30-215) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application IHC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000