CD177抗体;CD177 Polyclonal Antib

Description This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. References 1.Immunol Lett. 2016 Oct;178:122-30. 2.Immunohematology. 2015;31(3):128-9. Specification Aliases:NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP Entrez GeneID:57126 Swissprot:Q8N6Q3 clone:2F2C1 WB Predicted band size:46.4kDa Host/Isotype:Mouse IgG2b Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human CD177 (AA: extra 22-161) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application WB:1/500 - 1/2000 FCM:1/200 - 1/400 ELISA:1/10000