BCL10抗体;BCL10 Polyclonal Antib

Description This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. References 1.Cell Cycle. 2016;15(1):84-94. 2.Pathol Int. 2013 Mar;63(3):176-82. Specification Aliases:CLAP; mE10; CIPER; IMD37; c-E10; CARMEN Entrez GeneID:8915 Swissprot:O95999 clone:3C11F4 WB Predicted band size:26.3kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human BCL10 (AA: 98-234) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application FCM:1/200 - 1/400 ELISA:1/10000