PRKAA2抗体;PRKAA2 Polyclonal Ant

Description The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. References 1.Pathobiology. 2015;82(5):203-11. 2.Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):480-7. Specification Aliases:AMPK; AMPK2; PRKAA; AMPKa2 Entrez GeneID:5563 Swissprot:P54646 clone:8E11H5 WB Predicted band size:62.3kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human,Monkey Immunogen:Purified recombinant fragment of human PRKAA2 (AA: 453-552) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application WB:1/500 - 1/2000 IHC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000