SNAI1抗体;SNAI1 Polyclonal Antib

Description Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. References 1. Exp Cell Res. 2008 Aug 1;314(13):2448-53. 2. Mol Cell Biol. 2008 Aug;28(15):4772-81. Specification Aliases:SNA; SNAH; SLUGH2; dJ710H13.1; SNAI1 Entrez GeneID:6615 Swissprot:O95863 clone:6D2 WB Predicted band size:29kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human SNAI1 expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application ELISA:1/10000