SNAI2抗体;SNAI2 Polyclonal Antib

Description This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in -irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects. References 1. Biochem J. 2008 Dec 1;416(2):179-87. 2. Mol Biol Cell. 2008 Nov;19(11):4875-87. 3. Am J Pathol. 2009 Jun;174(6):2107-15. Specification Aliases:SLUG; WS2D; SLUGH1; MGC10182; SNAI2 Entrez GeneID:6591 Swissprot:O43623 clone:2H5 WB Predicted band size:30kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human SNAI2 expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application ELISA:1/10000