SLC4A4抗体;SLC4A4 Polyclonal Ant

Description This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states. Specification Aliases:KNBC; NBC1; NBC2; pNBC; HNBC1; hhNMC; SLC4A5; NBCe1-A Swissprot:Q9Y6R1 Host/Isotype:Rabbit IgG Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human, Mouse, Rat Immunogen:Fusion protein of human SLC4A4 Formulation:pH7.4 PBS, 0.05% NaN3, 40% Glycerol Application IHC:1/50-1/200 ELISA:1/2000-1/5000