CD207抗体;CD207 Polyclonal Antib

Description The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. References 1.Immunol Cell Biol. 2015 Oct;93(9):815-24. 2.J Immunol. 2011 Feb 1;186(3):1377-83. Specification Aliases:CLEC4K Entrez GeneID:50489 Swissprot:Q9UJ71 clone:1C5A1 WB Predicted band size:36.7kDa Host/Isotype:Mouse IgG2b Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human CD207 (AA: extra 155-328) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application FCM:1/200 - 1/400 ELISA:1/10000