FGFR1抗体;FGFR1 Polyclonal Antib

Description Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome. It is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. References 1. J Biol Chem. 2004 Jul 9;279(28):29325-35. 2. Arterioscler Thromb Vasc Biol. 2005 May;25(5):944-9. 3. Breast Cancer Res. 2007;9(2):R23. Specification Aliases:CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; HBGFR Entrez GeneID:2260 Swissprot:P11362 clone:3D4F7 WB Predicted band size:92kDa Host/Isotype:Mouse IgG2b Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant extracellular fragment of human FGFR1 (aa22-376) fused with hIgGFc tag expressed in HEK293 cells. Formulation:Ascitic fluid containing 0.03% sodium azide. Application ELISA:1/10000