DNMT3L抗体;DNMT3L Polyclonal Ant

Description CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. References 1.Clin Cancer Res. 2010 May 15;16(10):2751-9. 2.Epigenetics. 2009 Jul 1;4(5):322-9. Specification Entrez GeneID:29947 Swissprot:Q9UJW3 clone:5H4A5 WB Predicted band size:43.6kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human DNMT3L (AA: 147-386) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application ELISA:1/10000