EFCAB5抗体;EFCAB5 Polyclonal Ant

Description EF-CAB5(EF-hand calcium-binding domain-containing protein 5) is a 1,503 amino acid protein containing one EF-hand domain. Existing as four alternatively spliced isoforms, the gene encoding EF-CAB5 maps to human chromosome 17q11.2. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and LiFraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. Specification Swissprot:A4FU69 Host/Isotype:Rabbit IgG Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Synthetic peptide of human EFCAB5 Formulation:pH7.4 PBS, 0.05% NaN3, 40% Glycerol Application IHC:1/25-1/100 ELISA:1/5000-1/10000