MAP2K3抗体;MAP2K3 Polyclonal Ant

Description The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. References 1.Hum Mol Genet. 2013 Nov 1;22(21):4438-49. 2.Proteomics Clin Appl. 2010 Nov;4(10-11):816-28. Specification Aliases:MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2 Entrez GeneID:5606 Swissprot:P46734 clone:2E12D11 WB Predicted band size:39.3kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human MAP2K3 (AA: 1-138) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application IHC:1/200 - 1/1000 ICC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000