NME1抗体;NME1 Polyclonal Antibod

Description non-metastatic cells 1,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of nucleoside diphosphates,with a reduced expression in tumor progression to the metastatic phenotype,mutated in agressive neuroblastoma,expressed in lung carcinoma cell lines not in normal lung,pyrimidine biosynthetic pathway. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. Has tumor metastasis-suppressive capacity.Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. References 1. J Cell Biochem. 2009 Mar 1;106(4):666-72. 2. FEBS Lett. 2009 Sep 3;583(17):2789-92. 3. PLoS One. 2009 Nov 23;4(11):e7949. Specification Aliases:NB; AWD; NBS; GAAD; NM23; NDPKA; NDPK-A; NM23-H1; NME1 Entrez GeneID:4830 Swissprot:P15531 clone:4B2 WB Predicted band size:17kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human NME1 expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application IHC:1/200 - 1/1000 ICC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000