CHRNA4抗体;CHRNA4 Polyclonal Ant

Description This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. References 1.Epilepsy Res. 2014 Dec;108(10):1927-31. 2.J Pharmacol Exp Ther. 2014 Mar;348(3):410-20. Specification Aliases:EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4 Entrez GeneID:1137 Swissprot:P43681 clone:7B4H1 WB Predicted band size:70kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human CHRNA4 (AA: extra 29-242) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application ELISA:1/10000