GCG抗体;GCG Polyclonal Antibody

Description The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.Tissue specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. References 1. Int J Mol Med. 2008 Jul;22(1):127-32. 2. Physiol Behav. 2008 Aug 6;94(5):696-9. Specification Aliases:GLP1; GLP2; GRPP; GCG Entrez GeneID:2641 Swissprot:P01275 clone:2F9 WB Predicted band size:21kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human GCG expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application ELISA:1/10000