TRAF2抗体;TRAF2 Polyclonal Antib

Description The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. References 1.J Virol. 2014 Apr;88(7):3664-77. 2.Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov;27(11):1176-9. Specification Aliases:TRAP; TRAP3; MGC:45012 Entrez GeneID:7186 Swissprot:Q12933 clone:5C2C3 WB Predicted band size:55.8KD Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human TRAF2 (AA: 39-188) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application IHC:1/200 - 1/1000 ICC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000