- ￥600 - 3200
- 上海莼试
- CS-01Y74439
- 国产
- 2025年09月29日
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- 详细信息
- 技术资料
- 库存：
42
- 英文名：
Barnidipine (hydrochloride)
- CAS号：
104757-53-1
- 供应商：
上海莼试
- 保存条件：
4°C, away from moisture and light
- 规格：
10mM (in 1mL DMSO) 50mg 100mg
商品属性：
产品描述：
分子式:C27H29N3O6 • HCl
分子量:528.0
溶解度:≥ 16.3mg/mL in DMSO with gentle warming
储存条件:4°C, away from moisture and light
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.In vitro: The effects of barnidipine on L-type Ca(2+) current (I(Ca(L))) were investigated in rat ventricular cardiomyocytes. It was found that barnidipine reduced I(Ca(L)) in a concentration and voltage dependent manne. Barnidipine induced a leftward shift of the steady-state inactivation curve of I(Ca(L)) [1].In vivo: A previous study was conducted to investigate the influence of barnidipine treatment on early stage hypertension by determining the mesenteric and renal arteries as well as the kidney in L-NAME-induced hypertensive rats. Barnidipine was applied to rats after 2 weeks of L-NAME administration, and continued for the next 3 weeks concomitantly with L-NAME. Histopathological studies verified structural alterations in the arteries and the kidney. Moreover, a decrease in endothelial nitric oxide synthase expression was orved both in the arteries and kidney of hypertensive rats with barnidipine treatment [2].Clinical trial: In patients with hypertension and type 2 diabetes mellitus, it was found that barnidipine treatment led to a significant reduction in blood pressure. Data recorded with ABPM also showed a similar trend. Barnidipine + losartan could reduce the levels of Hs-CRP, TNF-α, sVCAM-1, sICAM-1, and isoprostanes [3].
注意事项：
抗逆滴加序列
每次向板内滴加抗原时，移液器滴头要与平面45度悬空，不要触碰到孔内的液体，由后向前依次滴加(即浓度由低往高滴加)。
抗感染反应期
抗原抗体在室温20~25℃下，必须反应30min以上，若环境温度低于室温，可将微量反应板置于恒温培养箱中，使二者充分反应。
旅游温度
磷酸盐缓冲液的pH值要在高压灭菌后进行滴定，往往在高压后pH值会有所改变，所以高压后再调一次pH值更为准确。磷酸盐缓冲液一经使用保存期不要超过3周。当pH<5.8时，红细胞会产生自凝现象;当pH>7.8时，图形洗脱加快，易造成肉眼观察产生误差;p H=7.2时，红细胞沉降最充分，图形最清晰。
当滴注 1%红细胞悬液时，应经常摇晃红细胞悬液，使红细胞均匀地分布在磷酸缓冲液中，以防止红细胞下降。
反应时间及温度
加入鸡红血球之后，反应板在室温(20~25℃)静置30~40min，对照孔血球下沉于孔底，即可判定结果。若室温达不到实验要求，需相应调整反应时间。当环境温度低于4℃时，红细胞发生自凝;高于37℃时，会发生反应物分离和红细胞溶血。
使用方法：
1.本蛋白酶抑制剂混合物为100×的储存液，使用时按照1:100的比例加入到裂解液中(例如，1ml裂解液中加入10μl蛋白酶抑制剂混合物)，混匀后即可使用。根据需要，0.5M的EDTA也按照1:100的比例加入到裂解液中（如用于检测金属蛋白酶活性，则不宜添加EDTA）。含有蛋白酶抑制剂混合物的裂解液宜现用现配，不宜配制后冻存待后续使用。
2. 待所需的抑制剂添加完毕混匀后，就可以开始进行哺乳动物组织的裂解和蛋白提取。
公司正在出售的产品：
| 货号 | CS-01Y74439 | 规格 | 10mM (in 1mL DMSO) 50mg 100mg |
| CAS号 | 104757-53-1 | 分子量 | 528.0 |
| 含量 | >98.00% | 别名 | YM 09730-5 |
| 分子式 | C27H29N3O6 • HCl | 化学名 | (4S)-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl] ester, monohydrochloride |
| 产地 | 国产 | 用途 | 仅供科研研究实验 |
分子式:C27H29N3O6 • HCl
分子量:528.0
溶解度:≥ 16.3mg/mL in DMSO with gentle warming
储存条件:4°C, away from moisture and light
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.In vitro: The effects of barnidipine on L-type Ca(2+) current (I(Ca(L))) were investigated in rat ventricular cardiomyocytes. It was found that barnidipine reduced I(Ca(L)) in a concentration and voltage dependent manne. Barnidipine induced a leftward shift of the steady-state inactivation curve of I(Ca(L)) [1].In vivo: A previous study was conducted to investigate the influence of barnidipine treatment on early stage hypertension by determining the mesenteric and renal arteries as well as the kidney in L-NAME-induced hypertensive rats. Barnidipine was applied to rats after 2 weeks of L-NAME administration, and continued for the next 3 weeks concomitantly with L-NAME. Histopathological studies verified structural alterations in the arteries and the kidney. Moreover, a decrease in endothelial nitric oxide synthase expression was orved both in the arteries and kidney of hypertensive rats with barnidipine treatment [2].Clinical trial: In patients with hypertension and type 2 diabetes mellitus, it was found that barnidipine treatment led to a significant reduction in blood pressure. Data recorded with ABPM also showed a similar trend. Barnidipine + losartan could reduce the levels of Hs-CRP, TNF-α, sVCAM-1, sICAM-1, and isoprostanes [3].
注意事项：
抗逆滴加序列
每次向板内滴加抗原时，移液器滴头要与平面45度悬空，不要触碰到孔内的液体，由后向前依次滴加(即浓度由低往高滴加)。
抗感染反应期
抗原抗体在室温20~25℃下，必须反应30min以上，若环境温度低于室温，可将微量反应板置于恒温培养箱中，使二者充分反应。
旅游温度
磷酸盐缓冲液的pH值要在高压灭菌后进行滴定，往往在高压后pH值会有所改变，所以高压后再调一次pH值更为准确。磷酸盐缓冲液一经使用保存期不要超过3周。当pH<5.8时，红细胞会产生自凝现象;当pH>7.8时，图形洗脱加快，易造成肉眼观察产生误差;p H=7.2时，红细胞沉降最充分，图形最清晰。
当滴注 1%红细胞悬液时，应经常摇晃红细胞悬液，使红细胞均匀地分布在磷酸缓冲液中，以防止红细胞下降。
反应时间及温度
加入鸡红血球之后，反应板在室温(20~25℃)静置30~40min，对照孔血球下沉于孔底，即可判定结果。若室温达不到实验要求，需相应调整反应时间。当环境温度低于4℃时，红细胞发生自凝;高于37℃时，会发生反应物分离和红细胞溶血。
使用方法：
1.本蛋白酶抑制剂混合物为100×的储存液，使用时按照1:100的比例加入到裂解液中(例如，1ml裂解液中加入10μl蛋白酶抑制剂混合物)，混匀后即可使用。根据需要，0.5M的EDTA也按照1:100的比例加入到裂解液中（如用于检测金属蛋白酶活性，则不宜添加EDTA）。含有蛋白酶抑制剂混合物的裂解液宜现用现配，不宜配制后冻存待后续使用。
2. 待所需的抑制剂添加完毕混匀后，就可以开始进行哺乳动物组织的裂解和蛋白提取。
公司正在出售的产品：
| Recombnant Human C4A, N-H | 病毒2 Spike蛋白RBD(N501Y)突变多肽 |
| DOCK10蛋白封闭多肽 | Phospho-PTK2 (Tyr861) Antibody Blocking Peptide |
| 重组人神经丝蛋白 | ARPC5 Antibody Blocking Peptide |
| 同源盒蛋白A1封闭多肽 | SDSL Antibody Blocking Peptide |
| 腺苷三磷酸结合盒转运体A1封闭多肽 | DVL1 Antibody Blocking Peptide |
| 磷酸化磷脂酰肌醇激酶封闭多肽 | phospho-DAP Kinase 1 (Ser308) Antibody Blocking Peptide |
| 小核核糖核蛋白E封闭多肽 | WASF3 Antibody Blocking Peptide |
| 活化半胱胺酸蛋白酶蛋白-2封闭多肽 | Lx1样蛋白封闭多肽 |
| 磷酸化粘着斑激酶封闭多肽 | Caspase-2 subunit p18 Antibody Blocking Peptide |
| 肌动蛋白相关蛋白2/3复合体亚基5封闭多肽 | SNRPE Antibody Blocking Peptide |
| 蓬乱蛋白1封闭多肽 | phospho-PIK3R1 (Tyr467) Antibody Blocking Peptide |
| L-丝氨酸脱氨酶封闭多肽 | ABCA1 Antibody Blocking Peptide |
| 磷酸化死亡相关蛋白激酶1封闭多肽 | Barnidipine (hydrochloride)HOXA1 Antibody Blocking Peptide |
| Verprolin同源结构域包含蛋白3封闭多肽 | Recombinant human AD7c-NTP protein, GST |
| SARS-CoV-2 (2019-nCoV) Spike RBD (N501Y) Mutated Peptide | DOCK10 Antibody Blocking Peptide |
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Barnidipine (hydrochloride)
￥600 - 3200
