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- SIGMA
- 美国
- F9786-1mL
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
瓶身
- 保质期：
coa
- 英文名：
SIGMA
- 库存：
999
- 供应商：
麦格生物
- CAS号：
106096-93-9
- 规格：
F9786-1mL
说明
一般描述
Fibroblast growth factor 2 (FGF2), a canonical member, belongs to the fibroblast growth factor family.
应用
Fibroblast Growth Factor-Basic Heparin Stabilized human has been used to culture Brown Norway rat yolk sac epithelial cells transformed with mouse sarcoma virus (BN/MSV). It has also been used in the preparation of serum-free mouse tubal epithelium growth medium (M-TE-GM) to culture primary tubal epithelium (TE) cells.
生化/生理作用
Fibroblast growth factor 2 (FGF2) participates in tissue development and repair.[1] It is also involved in embryonic development, angiogenesis, bone regeneration, stem cell self-renewal, and wound healing. The basic fibroblast growth factor (bFGF) plays a key role in the progression and maintenance of the nervous system.[4] FGF2 binds to the FGF receptor (FGFR) and activates the extracellular signal-regulated kinase (ERK) pathway, which controls cellular behavior, using heparan sulfates (HS)/heparin as a cofactor.[1] bFGF stimulates cell proliferation, differentiation, and migration in a variety of cell types.[4] In cultured astrocytes from rat brain, recombinant human basic fibroblast growth factor (rhbFGF) may induce nerve growth factor (NGF) secretion.[5] It is the heparin stabilized form of a natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.
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文献和实验A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor.
Thi H Nguyen et al.
Nature chemistry, 5(3), 221-227 (2013-02-21)
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