Phospho-SIRT1 (Ser47) 多克隆抗体

Using Phospho‐Motif Antibodies to Determine Kinase Substrates

the phosphorylation site; therefore, substrate?directed, phosphorylation?state?sensitive, motif?specific (?phospho?motif?) antibodies represent powerful tools to identify novel kinase substrates and to investigate mechanisms of substrate phosphorylation

Signaling Events Initiated by Kappa Opioid Receptor Activation: Quantification and Immunocolocalization Using Phospho-Selective KOR, p38 MAPK, and KIR

), and causes activation of KOR. Agonist-activated KOR becomes a substrate for G protein receptor kinase (GRK), which phosphorylates the Ser369 residue at the C-terminal tail of the receptor in the first step in the β-Arrestin-dependent desensitization cascade

三句话读懂一篇 CNS：长期玩手机，伤脑又折寿；运动、做家务和社交活动可降低痴呆风险

联合在 Nature Immunology 发表研究论文 Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity。 该研究将发现 SIRT1 介导的 DNA 结合域（DBD）去乙酰化是 IRF3/7 激活的关键步骤，其激活在衰老过程中受到抑制。通过使用 SIRT1 激动剂来改善 IRF3/IRF7 LLPS 的治疗方法，或可逆转老年人的先天