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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Acyclovir
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
59277-89-3
- 规格：
100mg/50mg/20mg/10mM*1mL in DMSO
| 规格： | 100mg | 产品价格： | ￥870.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥540.0 |
| 规格： | 20mg | 产品价格： | ￥360.0 |
| 规格： | 10mM*1mL in DMSO | 产品价格： | ￥380.0 |
是一类能够抑制疱疹病毒的胸苷激酶。
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:BMS-265246,a Cyclin-Dependent Kinase Inhibitor,Inhibits the Infection of Herpes Simplex Virus Type 1
成员:Lefang Jiang, Yang Yu, Zhuogang Li, Yarou Gao, Haonan Zhang, Mingxin Zhang, Weihua Cao, Qun Peng, Xulin Chen
论文因子:4.7 发表期刊:Viruses-Basel pmid:37631985
| 基本信息 | |
| CAS | No.59277-89-3 |
| 中文名称 | 阿昔洛韦 |
| 英文名称 | Acyclovir |
| 别名 | Acycloguanosine |
| 分子式 | C8H11N5O3 |
| 分子量 | 225.2 |
| 溶解性 | Soluble in DMSO ≥2mg/mL(Need ultrasonic) |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 261-685-1 |
| MDL | MFCD00057880 |
| SMILES | O=C1NC(N)=NC2=C1N=CN2COCCO |
| InChIKey | MKUXAQIIEYXACX-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15) |
| PubChem CID | 135398513 |
| 靶点 | HSV |
| 通路 | Anti-infection |
| 背景说明 | 是一类能够抑制疱疹病毒的胸苷激酶。 |
| 生物活性 | Acyclovir prevents bacterial infections during induction therapy for acute leukaemia. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1-4]. |
| In Vitro | Acyclovir(3-100 μM; 24-72 hours; Jurkat，U937，and K562 leukemia cells)treatment shows a dose- and time-dependent reduction of cell viability.Acyclovir(10-100 μM; 24-72 hours; Jurkat cells)treatment shows a delay/block in S phase and an increase of the sub-G1 peak.Acyclovir(10-100 μM; 24-72 hours; Jurkat cells)treatment activates caspase-3 and presences nuclear DNA fragmentation，thereby indicating apoptotic cell death[3].In HSV-infected cells，HSV thymidine kinase(HSV-TK)specifically phosphorylate Acyclovir to its monophosphate，and this activation confers a high degree of selectivity of the drugs. Thereafter，the monophosphate is further phosphorylated to the diphosphate(Acyclovir -DP)and triphosphate(Acyclovir -TP)by cellular kinases. The triphosphate is the fully activated metabolite that is toxic to the virus[4]. |
| 细胞实验 | Acyclovir(20 mg/kg; oral administration; three times daily; for 10 days; BALB/c mice)treatment in infected mice suppresses the development of skin lesions and results in a dissociation between DTH response and antibody production[1]. |
| 数据来源文献 | [1]. Li Z， et al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep;10(5):251-7. [2]. Suzuki M， et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61. [3]. Benedetti S， et al. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells， and enhances chemotherapeutic drug cytotoxicity. Life Sci. 2018 Dec 15;215:80-85. [4]. Hayashi K， et al. The role of a HSV thymidine kinase stimulating substance， scopadulciol， in improving the efficacy of cancer gene therapy. J Gene Med. 2006 Aug;8(8):1056-67. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:BMS-265246,a Cyclin-Dependent Kinase Inhibitor,Inhibits the Infection of Herpes Simplex Virus Type 1
成员:Lefang Jiang, Yang Yu, Zhuogang Li, Yarou Gao, Haonan Zhang, Mingxin Zhang, Weihua Cao, Qun Peng, Xulin Chen
论文因子:4.7 发表期刊:Viruses-Basel pmid:37631985
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