Tau (Phospho-Ser516/199) 多克隆抗体

v468 chapter 5 糖原合成酶激酶-3 的抑制

at 10, 25, and 50 μM). At 24 h post-treatment, celllysates were obtained; SDS-PAGE and Western blotting were performed as described in Section 3, Methods. AR-A014418dose-dependent decreases of phospho-β-catenin (Ser33/37) and phospho-glycogen synthase

v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平

3.1 and 3.6 ). This will provide a “specific activity” measurement relative to total protein in the cell, and is themost accurate measure of total GSK3 activity, or2. Immunoblot using antibodies to phospho-Ser21 (GSK3a)or phospho-Ser9 (GSK3b) (see Sections 3.1 –

大脑的秘密生活

说了这么多，那 Aβ和 AD 到底是什么关系呢?   老年斑和神经元纤维缠结是 AD 的重要病理特征。老年斑的主要组成物质是 Aβ，而神经元纤维缠结主要由过度磷酸化的 Tau 蛋白组成。   由于 AD 的发病机制非常复杂，目前对该病的发病机制没有明确的解释，多种理论都处于假说阶段。其主导地位的假说为 Aβ假说 [5]。这个假说认为 Aβ是诱导 AD 发生的起始因素。Aβ是经β-分泌酶和γ-分泌酶酶切产生。Aβ的大量生成、聚集和沉积会对神经元产生直接毒害作用，还会诱导