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- StressMarq
- 加拿大
- SPR-435
- 2025年11月14日
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- 详细信息
- 技术资料
- 保存条件：
-80ºC
- 保质期：
一年
- 英文名：
Superoxide Dismutase Monomers
- 库存：
大量
- 供应商：
StressMarq
- 规格：
100 µg/100 µg x2/100 µg x5
| 规格： | 100 µg | 产品价格： | 询价 |
|---|---|---|---|
| 规格： | 100 µg x2 | 产品价格： | 询价 |
| 规格： | 100 µg x5 | 产品价格： | 询价 |
| 产品名称 | SOD 蛋白 |
| 产品描述 |
重组人超氧化物歧化酶蛋白单体 |
| 应用范围 | WB, SDS-PAGE, In vivo assay, In vitro assay |
| 浓度 | 各批次不同，请详见说明书 |
| 标记物 | 无标签 |
| 性质 | 重组 |
| 来源物种 | 人 |
| 表达系统 | 大肠杆菌 (E. coli) |
| 纯度 | >95% |
| 蛋白长度 | 全长蛋白 |
产品特性
| 储存缓冲液 | PB pH 7.4 |
| 储存温度 | -80ºC |
| 运输温度 | 干冰. 运输: 该产品会与其他同订单产品分开发货. |
| 纯化方式 | 离子交换层析纯化 |
| Protein Size | 15.936 kDa |
| 引用该产品 | Human Recombinant SOD Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-435) |
| 分析证书 | 该蛋白已经通过SDS-PAGE检测证明纯度大于95%. |
| 其他相关信息 | 相关PFF请见目录号# SPR-470 |
生物学特性
| 别名 | Superoxide dismutase1 Protein Monomer, ALS1 Protein Monomer, SOD1 Protein Monomer, IPOA Protein Monomer |
| 研究领域 | 伴侣蛋白, 癌症, 氧化应激, 细胞信号传导, 蛋白质运输 |
| 细胞定位 | 线粒体, 细胞核, 细胞质 |
| Accession Number | NP_000445.1 |
| GeneID | 6647 |
| Swiss Prot | P00441 |
| 科研背景 | Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (7). SOD3 can also be distinguished by its heparin-binding capacity (1). Studies have shown that in vitro, Cu-Zn SOD (SOD1) fibrils are transduced into cells and function as seeds to trigger the aggregation of endogenously expressed SOD1 (9). |
| 参考资料 | 1. Adachi T., et al. (1992). Clin. Chim. Acta. 212: 89-102. 2. Barrister J.V., et al. (1987). Crit. Rev. Biochem. 22:111-180. 3. Furukawa Y., O'Halloran T. (2006). Antioxidants & Redo Signaling. Vol 8, No 5,6. 4. Gao B., et al. (2003). Am J Physiol Lung Cell Mol Physiol 284: L917-L925. 5. Hassan H.M. (1988). Free Radical Biol. Med. 5: 377-385. 6. Kurobe N., et al. (1990) Biomedical Research. 11: 187-194 7. Wispe J.R., et al. (1989) BBA. 994: 30-36. 8. Xiao-Hong Liu., et al. (1993) Brain Research. 625: 29-37. 9. Furukawa Y., et al. (2013) FEBS 587(16): 2500-2505. |
产品图片
人 SOD1 蛋白单体 (SPR-435) SDS-PAGE. 加样量: 2 ug
SOD1 前体原纤维 (PFFs) (SPR-470) 与 SOD1 单体 (SPR-435)混合的硫*磺素T检测. 前体原纤维聚集单体, 硫*磺素T荧光强度增强.
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超氧化物歧化酶蛋白单体
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