- ￥2024
- CUSABIO
- CN
- CSB-PA593881
- 2025年07月15日
- ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Synthesized peptide derived from N-terminal of Human DNMT3B.
- 亚型：
/
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
/
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
Q9UBC3
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500
- 浓度：
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点：
DNMT3B
- 抗体英文名：
DNMT3B Antibody
- 抗体名：
/
- 规格：
100μl
保存缓冲液
/功能
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing By similarity. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.Deloukas P., Nature 414:865-871(2001).
Li H., J. Biol. Chem. 281:19489-19500(2006).
Wijmenga C., Hum. Mutat. 16:509-517(2000).
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文献支持
DNMT3B抗体DNMT3B兔多抗抗体/抗体DNMT3B Antibody抗体
￥2024
