- ￥2024
- CUSABIO
- CN
- CSB-PA077444
- 2025年07月16日
- ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100
- Rabbit
- Human,Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Synthesized peptide derived from Human FGFR2.
- 亚型：
/
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
/
- 适应物种：
Human,Mouse
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
P21802
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100
- 浓度：
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点：
FGFR2
- 抗体英文名：
FGFR2 Antibody
- 抗体名：
FGFR2;BEK;KGFR;KSAM;Fibroblast growth factor receptor 2;FGFR-2;K-sam;Keratinocyte growth factor receptor;CD antigen CD332
- 规格：
100μl
保存缓冲液
/功能
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.Xavier Coumoul, Nucleic Acids Res., Jun 2005; 33: e102.
Nan E. Hatch, J. Biol. Chem., Sep 2006; 281: 27292 - 27305.
Sheri L. Kuslak, Development, Feb 2007; 134: 557 - 565.
Anita Petiot, Development, May 2005; 132: 2441 - 2450.
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文献和实验（杨希峰），Yang CY（杨春瑛） et al. Generation and characterization of monoclonal antibody against HIT3a （抗CD3单克隆抗体HIT3a的制备和特异性鉴定）， Acta Academiae Medicinae Sinicae （中国医学科学院学报），1993， 15：157-162.[6] Xiong D S（熊冬生），Yang C Z（杨纯正），Shao X F（邵晓枫）et al. Generation
人血小板膜糖蛋白IIbIIIa(GP-IIbIIIa/CD41+CD61)抗体
人血小板膜糖蛋白IIbIIIa(GP-IIbIIIa/CD41+CD61) 抗体 酶联免疫分析试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中血小板膜糖蛋白IIbIIIa(GP-IIbIIIa/CD41+CD61) 抗体 的含量。 实验原理： 本试剂盒应用双抗原夹心法测定标本中人血小板膜糖蛋白 IIbIIIa(GP-IIbIIIa/CD41+CD61) 抗体
是通过直接或间接地影响到该细胞的bcl-2的表达或功能，进而抑制细胞生长，诱导细胞凋亡，最终得以有效地挟制和杀灭肿瘤，这为抗体可用于联合化疗或降低病人耐药的临床治疗提供了有力的证据。【参考文献】[1]Golay JT，Clark EA，Beverley PC，et al. The CD20 （BP35）antigen is involved in activation of B cell from the G0 to the G1 phase of the cell cycle. J Immunol
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