- ￥440 - 1320
- CUSABIO
- CN
- CSB-PA774830ESR2HU
- 2025年07月10日
- ELISA, IHC; Recommended dilution: IHC:1:20-1:200
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant Human TIR domain-containing adapter molecule 2 protein (1-235AA)
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
Q86XR7
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA, IHC; Recommended dilution: IHC:1:20-1:200
- 浓度：
>95%,Antigen Affinity Purified
- 靶点：
TICAM2
- 抗体英文名：
TICAM2 Antibody
- 抗体名：
TRIF-related adapter molecule antibody
- 规格：
100μl/50μl/20μl
| 规格： | 100μl | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 50μl | 产品价格： | ￥880.0 |
| 规格： | 20μl | 产品价格： | ￥440.0 |
保存缓冲液
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.功能
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验双特异抗体(Bispecific antibody)的简介和制作方法
、双特异抗体简介双特异抗体（Bispecific antibody）是含有两个不同配体结合位点的免疫球蛋白分子。自然状态下不存在双特异性抗体，只能通过特殊方法进行制备。以往双特异抗体的制备方法有化学交联法，杂合F（ab'）2 分子法和鼠杂交瘤法等。化学交联法生产双特异抗体的异源性，批与批之间的不稳定性，以及抗体特异性易受某些修饰或不当连接而改变的特性，使得该法生产的双特异抗体不适于体内使用。以巯基交联蛋白酶消化片断F（ab'）生产的双特异杂交分子，成分虽较均一，但费时费力，且产量很低。杂交瘤法生产
上皮及间皮类常用标记抗体EPITHELIAL AND MESOTHELIAL MARKERSCK (MNF 116)- MNF-116 is a pan-cytokeratin antibody.- Source: Dakopatts.- Dilution 1:50.- Antigen retrieval method: HIER (pressure cooking) using EDTA.- Staining pattern: Cytoplasmic, typically
are washed away. 5. The antibody is detected by a ligand. The ligand is a molecule which can detect the antibody and is covalently coupled to an enzyme such as peroxidase. 6. This binds the test antibody and after free ligand is washed away. 7. The bound
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