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- Sino Biological
- 北京
- C31-18G
- 2026年01月26日
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- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
CDK4/CyclinD3, Active
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
10 µg
蛋白名称：CDK4/CyclinD3, Active
蛋白构建：Recombinant full length human CDK4 and CyclinD3 were co-expressed by baculovirus in Sf9 cells using an N-terminal GST tag on both proteins.
表达宿主：Baculovirus-Insect Cells
蛋白分子量：CDK4 ~58 kDa; CyclinD3 ~58 kDa
蛋白NP号：NM_000075 ,NM_001760
蛋白氨基酸序列：Full Length
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文献和实验Two-hybrid analysis of genetic
protein sequences suggested residues that may be important for specific interactions with certain Cdis.Second,Cdi3,Drosophila Cyclin D,interacted much more strongly with human Cdk4 than with any of the other Cdks in the panel including the Drosophila Cdks
Evaluation of Alterations in the Tumor Suppressor Genes INK4A and INK4B in Human Bladder Tumors
for the p16 and the p15 proteins, respectively (12 –14 ). These protein products form binary complexes exclusively with Cdk4 and Cdk6, inhibiting their function and, by doing so, inhibiting pRB phosphorylation during G1. Additional complexity results
Two-hybrid analysis of genetic regulatory networks
to be involved in the disease. Recently, Reymond and Brent undertook a test of this idea (Reymond and Brent, 1995). They studied the protein encoded by the INK4 human tumor suppressor gene, p16. Wild type p16 interacts with two human Cyclin-dependent kinases, Cdk4
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