人CCR6重组蛋白CKRL3;CMKBR6;GPR29;ST

英文名称：

Recombinant Human C-C chemokine receptor type 6 (CCR6)-VLPs (Active)

品名简称：

Recombinant Human CCR6 protein-VLPs (Active)

货号：

CSB-MP004845HU

规格:

20μg

价格：

3348

LC-MS/Western Blot：

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SDS-PAGE：

CSB-MP004845HU is detected by Mouse anti-6*His monoclonal antibody. The two bands respectively correspond to monomer, Homodimer.

纯度：

The purity information is not available for VLPs proteins.

内毒素：

Less than 1.0 EU/μg as determined by LAL method.

生物活性：

Measured by its binding ability in a functional ELISA. Immobilized Human CCR6 at 10 μg/mL can bind Anti-CCR6 recombinant antibody (CSB-RA004845MA1HU). The EC50 is 44.79-56.10 ng/mL. The VLPs (CSB-MP3838) is negative control.

基因名：

CCR6

Uniprot No.：

P51684

别名：

CKRL3;CMKBR6;GPR29;STRL22

种属：

Homo sapiens (Human)

蛋白长度：

Full Length

来源：

Mammalian cell

分子量：

42.5 kDa

表达区域：

1-374aa

氨基酸序列：

MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM

蛋白标签：

C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)

产品提供形式：

Lyophilized powder

缓冲液：

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4.

储存条件：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.

保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

货期：

3-7 business days

注意事项：

The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex.Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).

功能1：

Act as a receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Act as a receptor for non-chemokine ligands such as beta-defensins.

功能2：

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文献：

"Identification of CCR6, the specific receptor for a novel lymphocyte- directed CC chemokine LARC." Baba M., Imai T., Nishimura M., Kakizaki M., Takagi S., Hieshima K., Nomiyama H., Yoshie O. J. Biol. Chem. 272:14893-14898 (1997) "Molecular cloning and RNA expression of two new human chemokine receptor- like genes." Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G. Biochem. Biophys. Res. Commun. 227:846-853 (1996) "Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27." Liao F., Lee H.-H., Farber J.M. Genomics 40:175-180 (1997)

研究领域：

Cancer

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