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- 详细信息
- 文献和实验
- 技术资料
- 亚型:
IgG2a, kappa
- 形态:
Liquid
- 保存条件:
at-20℃
- 适应物种:
Human
- 库存:
99
- 宿主:
Mouse
- 应用范围:
ELISA
- 浓度:
见说明
- 抗体英文名:
Anti-Human APP/Amyloid beta Monoclonal antibody (22D12)
- 规格:
50-100ug
小鼠抗人APP/Amyloid beta单克隆抗体(克隆号22D12)上海圻明生物优势供应欢迎咨询。配对抗体小课堂:
Paired antibodies are two antibodies that can bind to an antigenic molecule at the same time. Specifically:
Paired antibodies are commonly used in sandwich ELISA experiments
An antigenic molecule usually has multiple epitopes, and different antibodies can target different epitopes
When two antibodies are able to bind to different epitopes of the same antigenic molecule at the same time, the two antibodies are called paired antibodies
However, not all antibodies against different epitopes can be paired antibodies. Sometimes, when an antibody binds to an antigen, it may cause the configuration of other binding sites to change, making it impossible for other antibodies to bind properly
Steric hindrance effects may also result in two antibodies with close binding sites not being able to bind to the antigen at the same time
Therefore, the preparation of paired antibodies usually requires two steps: first the antibody is prepared, and then the paired antibody is screened
Screening of paired antibodies is typically performed using a sandwich ELISA method of bispecific antibodies, in which different combinations of antibodies are tested to determine which antibodies can be successfully paired
Paired antibodies have important applications in immunology research and diagnostics, especially in assays that require high specificity and sensitivity.

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文献和实验了相应的伴随/补充诊断抗体:28-8、22C3、SP142、SP263(克隆号,其中 Bavencio 无指定 PD-L1 诊断抗体)这 4 个 PD-L1 单抗,用于 PD-L1 表达水平的 IHC 检测[2]。国际肺癌研究协会(IASLC)牵头发起的 Blueprint 1项目对上述 4 种 PD-L1 IHC 检测克隆进行了比较。28-8(ab205921,Abcam)、22C3 和 SP263 显示出相似的肿瘤细胞阳性染色百分比,而 SP142(ab228462,Abcam)相对特殊,相较
快速老化痴呆模型小白鼠SAMP8, SAMP10老化特征及其相关研究进展
(GR alpha)和盐皮质激素受体(MR) 16种基因mRNAs在P8海马和皮层中的表达状况,其中基因TGF-beta 1, IL-1 alpha, TNF-beta, c-fos, NCAM-180, PS-1 和 APP mRNA与R1相比在P8中正常表达,apoE, GR alpha 和 MR mRNAs特别是GR alpha在P8海马中明显低表达,而Bcl-2 alpha, PS-2 和tau蛋白 mRNA则明显高表达;炎性细胞因子(IL-1α/β, IL-6, TNF-β),alpha
-8、22C3、SP142、SP263(克隆号,其中 Bavencio 无指定 PD-L1 诊断抗体)这 4 个 PD-L1 单抗,用于 PD-L1 表达水平的 IHC 检测[11]。目前在 NSCLC(非小细胞肺癌)治疗中,每个 PD 抑制剂都开发了相应的特异性 PD-L1 免疫组化(IHC)检测方法,以评估 NSCLC 中恶性肿瘤和 / 或免疫细胞上的 PD-L1 表达水平。前文已经提到 OPDIVO(nivolumab,BMS) 在 NSCLC 患者的治疗中获得了极大的成功,且疗效与 PD
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