- 询价
- KA&M BIO
- MAB4707
- 2025年10月12日
- IHC,WB
- Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG2a, kappa
- 形态：
Liquid
- 保存条件：
at-20℃
- 库存：
99
- 宿主：
Mouse
- 应用范围：
IHC,WB
- 浓度：
见说明
- 抗体英文名：
Anti-Nav1.3 Na+ channel Monoclonal antibody (N45B/45)
- 规格：
50-100ug
小鼠抗Nav1.3 Na+ channel单克隆抗体(克隆号N45B/45)上海圻明生物优势供应欢迎咨询。配对抗体小课堂：
Paired antibodies are two antibodies that can bind to an antigenic molecule at the same time. Specifically:
Paired antibodies are commonly used in sandwich ELISA experiments
An antigenic molecule usually has multiple epitopes, and different antibodies can target different epitopes
When two antibodies are able to bind to different epitopes of the same antigenic molecule at the same time, the two antibodies are called paired antibodies
However, not all antibodies against different epitopes can be paired antibodies. Sometimes, when an antibody binds to an antigen, it may cause the configuration of other binding sites to change, making it impossible for other antibodies to bind properly
Steric hindrance effects may also result in two antibodies with close binding sites not being able to bind to the antigen at the same time
Therefore, the preparation of paired antibodies usually requires two steps: first the antibody is prepared, and then the paired antibody is screened
Screening of paired antibodies is typically performed using a sandwich ELISA method of bispecific antibodies, in which different combinations of antibodies are tested to determine which antibodies can be successfully paired
Paired antibodies have important applications in immunology research and diagnostics, especially in assays that require high specificity and sensitivity.
小鼠抗Nav1.3 Na+ channel单克隆抗体(克隆号N45B/45)更多优势产品欢迎新老客户选购。
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文献和实验Functional Reconstitution of the Human Epithelial Na+ Channel in a Mammalian Expression System
recombinant ion channels in a mammalian expression system quantifying channel activity with patch clamp electrophysiology. Here, we describe investigation of the human epithelial Na+ channel heterologously expressed in Chinese hamster ovary cells.
Use of ion-channel modulating agents to study cyanobacterial Na+-K+ fluxes
levels increased exponentially with rising alkalinity, with K+ levels being maximal for optimal growth pH (∼8). At standardized pH conditions, the increase in cellular Na+ , as induced by NaCl at 10 mM, was coupled by the two sodium channel-modulating
PNAS 背靠背：颜宁、潘晓静揭示人体钠泵突变热点，为癫痫和心脏疾病精准医疗带来结构生物学基础
在 Science 杂志发表了题为 Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1 的研究论文， 揭示了首个人源 Nav 通道 Nav 1.4 与其调节亚基 β1 复合物的冷冻电镜结构。 图片来源：Science2020 年 6 月 8 日，颜宁团队在 PNAS 发表题了为 Employing NaChBac for cryo-EM analysis of toxin action on voltage
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