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- 详细信息
- 技术资料
- 免疫原:
The antiserum was produced against synthesized peptide derived from human C-RAF around the phosphorylation site of Ser621. AA range:591-640
- 形态:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 保存条件:
-20°C/1 year
- 克隆性:
Polyclonal
- 适应物种:
Human,Mouse,Rat,Monkey
- 保质期:
1年
- 宿主:
Rabbit
- 应用范围:
WB,IHC-p,IF,ELISA
- 浓度:
1 mg/ml
- 靶点:
RAF1
- 抗体英文名:
Raf-1 (phospho Ser621) rabbit pAb
- 抗体名:
RAF proto-oncogene serine/threonine-protein kinase
- 规格:
50ul
Raf-1 proto-oncogene, serine/threonine kinase(RAF1) Homo sapiens This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008],
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Raf-1 (phospho Ser621) rabbit pAb
¥900






