GQN-B37-Me

GQN-B37-Me 产品活性：GQN-B37-Me 是一种 MCL-1 抑制剂。GQN-B37-Me 可诱导 caspase 依赖性细胞凋亡。GQN-B37-Me 在 H929 (IC50 = 3.71 μM) 和 MV-4-11 (IC50 = 5.57 μM) 细胞中表现出显著的细胞毒性。GQN-B37-Me 可用于白血病的研究。 产品来源： www.medchemexpress.cn/gqn-b37-me.html 研究领域：Apoptosis 作用靶点：Bcl-2 Family In Vitro: GQN-B37-Me (1-20 μM, 24 h) induces late apoptosis in MV-4-11 cells in a clear dose-dependent manner. GQN-B37-Me (10-40 μM, 10 h) is able to block the MCL-1/BIM interaction in H929 cells and consequently induces caspase-dependent apoptosis. In Vivo: GQN-B37-Me (12.5-50 mg/kg, i.p., every 2 days over a 20 day) reduces tumor volume in a MV-4-11 xenograft mouse leukemia model. 相关产品：Venetoclax | Navitoclax | Polyinosinic-polycytidylic acid | Sulforaphane | S63845 | ABT-737 | A-1331852 | Chlorin e6 | BT2 | BAI1 | A-1155463 | AZD-5991 | Estradiol benzoate | Amantadine | MIK665 | Benzbromarone | Obatoclax Mesylate | Chelerythrine chloride | Digitoxin | BI-3802 | WEHI-539 hydrochloride | AZD4320 | DT2216 | Dehydrocorydaline | Bax inhibitor peptide V5 | Gambogic Acid | Tapotoclax | Gossypol | A-1210477 | Daphnetin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。