S. aureus gyrB - for 100 assay

In vivo evaluation of drug lead candidates by intravenous continuous infusion

reduction of viable S. aureus cells from the infected kidney. However, reductions of 4 and 5 log were achieved with 100 and 150 µg/hr, respectively. Dosing of 150 µg/hr showed 40% of the kidneys with no viable S. aureus while dosing of 100 µg/hr exhibited 20

全细胞靶点筛选抗生素新药的方法A target-specific whole cell assay for antibacterial drug discovery

of only selecting compounds that are able to penetrate cells and reach intracellular targets. Despite this advantage, most of the compounds found in whole cell screens show poor target selectivity. Here we describe a target selective S. aureus whole cell assay

生物发光和化学发光在生物技术中的应用

. (1991) Biosens. Bioelectron. 6, 21–29 47. Genetically engineered whole-cell sensing systems: coupling biological recognition with reporter genes. Daunert, S. et al. (2000) Chem. Rev. 100, 2705–2738  48. Reporter gene assays for algal-derived toxins