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文献和实验Methods for Adeno-Associated Virus-Mediated Gene Transfer into Muscle
Gene therapy vectors based on adeno-associated virus (AAV) are being used to successfully transduce a number of different tissues, including muscle (1 ). The first demonstration of muscle transduction by recombinant AAV (rAAV) was reported
for small disease genes, such as factor IX in hemophilia B. Despite this seemly “narrow” area of application, recombinant AAV (rAAV) has still attracted tremendous interest in the field of gene therapy and has become one of the mainstream vectors on trial
Tumor necrosis factor-α (TNF-α) is a cytokine (CK) that possesses a wide variety of biological activities, including potent antitumor activities (1 ) and immunomodulatory properties mediated through its binding to two TNF receptors (p55
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