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文献和实验Overview of Receptor Allosterism
modulators on orthosteric ligand dissociation kinetics. (A ) Enhancement of the dissociation rate of [3 H]yohimbine from the human α2A receptor expressed in CHO cell membranes by the modulator 5‐( N ‐ethyl‐ N ‐isopropyl)‐amiloride (EPA). Data taken
via a receptor-mediated process that involves the interaction of a carrier protein secreted by the liver, retinol-binding protein (RBP), and a receptor/channel that is the gene product of STRA6 (stimulated by retinoic acid 6). Following
Introduction of human 14-3-3 proteins
acid sequence of human 14-3-3 protein eta was highly homologous to that of previously reported bovine and rat 14-3-3 proteins with only two amino acid differences.The sequence carries structural features as putative regions responsible for activation
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