Recombinant Human Melanoma Cel

Single-Molecule Methods to Study Cell Adhesion Molecules

forces of cell adhesion molecules, which may shed insights on molecular mechanisms of cellular adhesion. In addition, single-molecule techniques enable us to observe the detailed distributions of individual molecular behaviors that cannot be readily

Adhesion Molecule Expression on Cytokine-Stimulated Human Endothelial Cells

Leukocyte adhesion to vascular endothelial cells is central in regulating inflammatory responses. Endothelial cells line the vasculature and cover over 1000 m2 in the average adult (1 ). These cells were long thought to be inert, acting

细胞粘着分子(cell adhesion molecule, CAM)

参与细胞粘着的分子称为细胞粘着分子。 自从N-CAM被发现之后,陆续发现了一些新的细胞粘着分子,如Ng-CAM是神经胶质细胞粘着分子,L-CAM是肝细胞的细胞粘着分子,I-CAM是普遍存在的一种细胞粘着分子,它的配体是LFA-1;而LEC-CAM是白细胞及其它循环细胞中发现的细胞粘着分子。上述细胞粘着分子都是糖蛋白,在细胞外结构域都有与肽共价结合的糖基。根据细胞粘着分子的作用方式可分为三个家族:①免疫球蛋白超家族,如V-CAM、Ng-CAM、I-CAM和L1等;②钙粘着蛋白家族，如E