Recombinant Human Major Histoc

Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenoge

to result predominately from a human anti-mouse major histocompatibility complex (MHC) class II reactivity. Our recent development of NOD-scid IL2rγ null β2m null and NOD-scid IL2rγ null Ab null stocks of mice now make it possible to investigate

Study of the Allogeneic Response Induced by Endothelial Cells Expressing HLA Class II After Lentiviral Transduction

by the expression of major histocompatibility complex (MHC) molecules in the donor organ. Graft microvascular endothelial cells express both HLA class I and class II molecules. They are the first target of the allogeneic response because of their vascular

Generation of Recombinant Immunotoxins for Specific Targeting of Tumor-Related Peptides Presented by MHC Molecules

in immunotherapy because of their highly restricted fine specificity. Expression of specific peptides in complex with MHC class I molecules on cells was shown to be associated with cancer and autoimmune disorders (1 –8 ). For example, human melanomas express