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文献和实验Actl- D 和截短的 Act1 启动子(ActlF ) 均被用来驱动以必表达[12, 18],但尚未有这些转基因株系详细分析的报道。 在谷类作物中得到鉴定和应用的其他类型的组成型表达的启动子还有:携带 Ubi 第一个内含子的玉米 H2B 启动子 [25]、玉米 Adh1 启动子[8 , 9 ] 、水稻细胞色素 c 启动子(OsCc1 ) [72],以及来自地三叶草矮化病毒(SCSV) 的一系列调控序列[73]。 3. 组织特异性基因的表达 在自然状态下,依据基因产物的作用
Incorporation of Immunomodulators into Plasmid DNA Vaccines
the particular pathogen by the vaccine candidate. The presence of IL-12, IL-15, IL-18, or interferon-gamma (IFN-γ) are critical in the development of Th1 responses that are directed toward cell-mediated immunity (2 ), and the presence of IL-4, IL-5, and IL-10
after specifically interacting with its receptors. Human IL-2 is a 133-amino acid polypeptide with a molecular mass of 15-18 kDa. IL-2 signaling is mediated by a multichain receptor complex consisting of an alpha (CD25), beta (CD122), and gamma (CD132) chain. The IL
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