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- 2025年07月11日
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文献和实验Inhibition of HIV Infection by Lectin Binding to gp120
Human immunodeficiency virus (HIV) is the causative agent of AIDS (acquired immunodeficiency syndrome). The polypeptide precursor gp160 of HIV-1 forms the external glycoprotein, gp120 and the transmembrane glycoprotein, gp41 (1 ). Sequence
2+ ) (Leitinger et al., Leitinger Biochim Biophys Acta 1498:91–98, 2000). Here we describe a protocol to detect biotinylated recombinant HIV-1 gp120 binding to integrin α4 β7 in both primary cells and cell lines expressing the gut-homing receptor.
Recombinant Immunotoxins in the Treatment of Cancer
) have been produced that kill different types of cancer cells, as well as human immunodeficiency virus (HIV)-infected cells, taking advantage of gp120 on the surface of HIV-infected cells.
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