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文献和实验人中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin, NGAL)是Kjeldsen等人于1993年在中性粒细胞的特殊颗粒中首先发现的。以往的研究表明NGAL与炎症、胚胎发育、免疫应答、趋化作用、信号转导以及多种肿瘤的发生与发展等过程密切相关。NGAL在乳腺癌、食管癌、结直肠癌、胃癌、慢性粒细胞性白血病等细胞系中均过表达,并在癌细胞的浸润与不良分化中发挥重要的作用。进一步研究证实,NGAL是存在于中性粒细胞和某些上皮
Purification, Measurement of Concentration, and Functional Complement Assay of Human Ficolins
Ficolins constitute a group of lectins involved in innate immunity. L-Ficolin, H-ficolin, and M-ficolin are present in human serum. The human ficolins differ in carbohydrate-binding specificity, but they have in common the ability
Introduction of human 14-3-3 proteins
The human and bovine 14-3-3 eta protein mRNAs are highly conservedEvolutionary conservation of the 14-3-3 proteinExpression and structural analysis of 14-3-3 proteinsCrystal structure of the zeta isoform of the 14-3-3 proteinStructure of a 14
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