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文献和实验Regulated Expression of Plasmid-Based Gene Therapies
, local expression. Examples include induction of collateral vessel growth following injection of vascular endothelial growth factor (VEGF) plasmids into regions of ischemic muscle (3 ) and induction of humoral and cell-based immunity following
Dual Vector Expansion of the Recombinant AAV Packaging Capacity
vectors such as adenovirus and herpes simplex virus (13 ). Regulated myocardial transgene expression has also been demonstrated with an AAV vector containing glucocorticoid response elements in rat heart (14 ).
A chemokine-driven positive feedback loop organizes lymphoid follicles
Lymphoid follicles are B-cell-rich compartments of lymphoid organs that function as sites of B-cell antigen encounter and differentiation. CXC chemokine receptor-5 (CXCR5) is required for B-cell migration to splenic
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