Cleaved-COL4A3 (L1425) rabbit pAb

Cleaved-COL4A3 (L1425) rabbit

pAb
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  • ¥900
  • AAB
  • 上海
  • A12627
  • 2025年07月12日
  • WB,ELISA
  • Rabbit
  • Human
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    • 详细信息
    • 技术资料
    • 免疫原

      The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3. AA range:1376-1425

    • 形态

      Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

    • 保存条件

      -20°C/1 year

    • 克隆性

      Polyclonal

    • 适应物种

      Human

    • 保质期

      1年

    • 宿主

      Rabbit

    • 应用范围

      WB,ELISA

    • 浓度

      1 mg/ml

    • 靶点

      COL4A3

    • 抗体英文名

      Cleaved-COL4A3 (L1425) rabbit pAb

    • 抗体名

      Collagen alpha-3(IV) chain

    • 规格

      50ul

    collagen type IV alpha 3 chain(COL4A3) Homo sapiens Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal r

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