- ￥1130 - 23600
- TargetMol
- 美国
- T62281
- 2025年07月09日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
PARP-1-IN-2
- 库存：
10
- 供应商：
TargetMol
- CAS号：
684234-55-7
- 规格：
100 mg/50 mg/1 mg/25 mg/1 mL/5 mg/500 mg/10 mg
| 规格： | 100 mg | 产品价格： | ￥11700.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥8730.0 |
| 规格： | 1 mg | 产品价格： | ￥1130.0 |
| 规格： | 25 mg | 产品价格： | ￥6390.0 |
| 规格： | 1 mL | 产品价格： | ￥2590.0 |
| 规格： | 5 mg | 产品价格： | ￥2490.0 |
| 规格： | 500 mg | 产品价格： | ￥23600.0 |
| 规格： | 10 mg | 产品价格： | ￥3990.0 |
Product Introduction
Bioactivity
英文名:PARP-1-IN-2
描述:PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cellular assays.PARP-1-IN-2 induced apoptosis in A549 cells.
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文献和实验Phenotypic Characterization of Parp-1 and Parp-2 Deficient Mice and Cells
Poly(ADP-ribosyl)ation is a post-translational modification of proteins mediated by Poly(ADP-ribose) polymerases (Parps), a family of 17 members. Among them, Poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 are so far the sole enzymes
A general method to express and purify full-length human poly(ADP-ribose) polymerase-1 (PARP-1), individual PARP-1 domains, and groups of PARP-1 domains from Escherichia coli cells is described. The procedure allows for robust production
Regulation of Chromatin Structure by PARP-1
PARP-1 is the most abundantly expressed member of a family of proteins that catalyze the transfer of ADP-ribose units from NAD+ to target proteins. Numerous studies on PARP-1 have revealed its critical roles in regulating various molecular
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