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- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
NITD-916
- 库存：
10
- 供应商：
TargetMol
- CAS号：
1614262-83-7
- 规格：
50 mg/1 mg/25 mg/10 mg/5 mg
| 规格： | 50 mg | 产品价格： | ￥13800.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2350.0 |
| 规格： | 25 mg | 产品价格： | ￥11200.0 |
| 规格： | 10 mg | 产品价格： | ￥7790.0 |
| 规格： | 5 mg | 产品价格： | ￥5630.0 |
Product Introduction
Bioactivity
英文名:NITD-916
描述:NITD-916 is an orally active and highly lipophilic inhibitor of Mycobacterium enoyl reductase InhA with an IC50 of 570 nM.NITD-916 is a potent 4-hydroxy-2-pyridone derivative that forms a ternary complex with InhA and NADH, preventing access to the fatty acyl substrate-binding pocket.NITD-916 exhibits antituberculosis activity.
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文献和实验Transposon Mutagenesis in Clostridium difficile
Genetic manipulation of Clostridium difficile is notoriously difficult, currently there is only one reliable method for generating random mutations in the organism and that is to use the conjugative transposon Tn916 . Tn916 enters the genome
0.897 0.901 0.905 0.908 0.911 0.914 0.916 0.918 0.920 α=1.0% 0.835 0.844 0.851 0.858 0.863 0.868 0.873 0.878 0.881 0.884 0.888 0.891 n 27 28 29 30 31 32 33 34 35 36 37 38 α=1.00% 0.935 0.936 0.937 0.930 0.940 0.941 0.942 0.943 0.944 0.945 0.946 0.947 α
Transformation of mycoplasmas was not clearly demonstrated until 1987 when Dybvig and Cassell were able to show the introduction of the Gram-positive transposon Tn916 into Acholeplasma laidlawii and Mycoplasma pulmonis
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