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Sino Biological 新冠病毒Spike重组蛋白 His标签 新冠S蛋白

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  • ¥4500 - 37830
  • Sino Biological已认证
  • 北京
  • 40590-V08B
  • 2026年01月26日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      -20℃ to -80℃

    • 保质期

      12个月

    • 英文名

      Recombinant SARS-CoV-2 (2019-nCoV) Spike S2 ECD-His Recombinant Protein

    • 库存

      99

    • 供应商

      北京义翘神州科技股份有限公司

    • 规格

      1.00 mg/100.00 µg

    规格:1.00 mg产品价格:¥37830.0
    规格:100.00 µg产品价格:¥4500.0

    SARS-CoV-2 (2019-nCoV) |新冠病毒 Spike Protein (S2 ECD, His tag): 产品信息

    纯度:> 90 % as determined by SDS-PAGE.
    产品细节图片1
    内毒素:<1.0 EU per μg protein as determined by the LAL method.
    生物活性:Testing in progress
    蛋白构建:A DNA sequence encoding the 2019-nCOV Spike Protein (S2 ECD) was expressed with a polyhistidine tag at the C-terminus.
    表达宿主:Baculovirus-Insect Cells
    种属:2019-nCoV
    预测 N 端:Ser
    分子量:The recombinant 2019-nCoV Spike Protein (S2 ECD, His tag) consists of 539 amino acids and predicts a molecular mass of 59.37 kDa.
     
     

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    图标文献和实验
    该产品被引用文献
    1, Chen, Y; et al. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell, PMID: 33171099
    2, Gao, L; et al. The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity. Signal transduction and targeted therapy, PMID: 33686064
    3, Dejnirattisai, W; et al. The antigenic anatomy of SARS-CoV-2 receptor binding domain. Cell, PMID: 33756110
    4, Pradenas, E; et al. Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes. Med (New York, N.Y.), PMID: 33554155
    5, Williams, WB; et al. Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, PMID: 34019795
    6, Jennewein, MF; et al. Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects. Cell reports, PMID: 34237283
    7, Tong, P; et al. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. Cell, PMID: 34332650
    8, Nassir, N; et al. Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19. iScience, PMID: 34458692
    9, Kramer, KJ; et al. Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition. Cell reports, PMID: 34592170
    10, Verma, A; et al. Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation. Cell reports, PMID: 34706272
    11, Langellotto, F; et al. A Modular Biomaterial Scaffold-Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS-CoV-2 Antigens. Advanced healthcare materials, PMID: 34605223 1
    2, Shroff, RT; et al. Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors. Nature medicine, PMID: 34594036 1
    3, Chang, X; et al. A Novel Double Mosaic Virus-like Particle-Based Vaccine against SARS-CoV-2 Incorporates Both Receptor Binding Motif (RBM) and Fusion Domain. Vaccines, PMID: 34835218 1
    4, Wang, X; et al. Temporal transcriptomic analysis using TrendCatcher identifies early and persistent neutrophil activation in severe COVID-19. JCI insight, PMID: 35175937 1
    5, Walters, JN; et al. Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates. Vaccine, PMID: 35428500 1
    6, Chen, Y; et al. Immune recall improves antibody durability and breadth to SARS-CoV-2 variants. Science immunology, PMID: 35549298 1
    7, Junker, D; et al. Antibody binding and ACE2 binding inhibition is significantly reduced for both the BA1 and BA2 omicron variants. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, PMID: 35717657 1
    8, Zimmerman, O; et al. mRNA vaccine boosting enhances antibody responses against SARS-CoV-2 Omicron variant in individuals with antibody deficiency syndromes. Cell Reports Medicine, PMID: 35688161 1
    9, Tzeng, TT; et al. A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection. NPJ vaccines, PMID: 35662254
    20, Wang, C; et al. The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia. mBio, PMID: 35762593
    21, Jia, L; et al. Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunity. Gut microbes, PMID: 36100957 2
    2, Sano, K; et al. SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals. Nature communications, PMID: 36050304 2
    3, LaSalle, TJ; et al. Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patients. Cell Reports Medicine, PMID: 36208629 2
    4, Langel, SN; et al. Dam-Infant Rhesus Macaque Pairs to Dissect Age-Dependent Responses to SARS-CoV-2 Infection. ImmunoHorizons, PMID: 36547390 2
    5, Carreño, JM; et al. An inactivated NDV-HXP-S COVID-19 vaccine elicits a higher proportion of neutralizing antibodies in humans than mRNA vaccination. Science translational medicine, PMID: 36791207 2
    6, Jia, T; et al. Stable and durable antibody responses in SARS-recovered donors vaccinated with inactivated SARS-CoV-2 vaccine. Journal of medical virology, PMID: 36905115 2
    7, Buffington, J; et al. Identification of nurse shark VNAR single-domain antibodies targeting the spike S2 subunit of SARS-CoV-2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, PMID: 37191949 2
    8, Zhou, F; et al. Impact of ageing on homologous and human-coronavirus-reactive antibodies after SARS-CoV-2 vaccination or infection. NPJ vaccines, PMID: 38378953 2
    9, Jung, W; et al. SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner. Cell reports, PMID: 39213155
    30, Tong, X; et al. Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaques. iScience, PMID: 39224511
    31, Barnett, C; et al. Impaired immune responses in the airways are associated with poor outcome in critically ill COVID-19 patients. ERJ Open Research, PMID: 38978558 3
    2, Dolange, V; et al. A surrogate ELISA to select high titer human convalescent plasma for treating immunocompromised patients infected with SARS-CoV-2 variants of concern. The Journal of infectious diseases, PMID: 39749487 3
    3, Carreño, JM; et al. XBB.1.5 monovalent vaccine induces lasting cross-reactive responses to SARS-CoV-2 variants such as HV.1 and JN.1, as well as SARS-CoV-1, but elicits limited XBB.1.5 specific antibodies. mBio, PMID: 40042313
    相关实验
    • 利用 Millicell 培养小室培养皮肤及肺类器官的实验方案

      proteins of respiratory syncytial virus is mediated by ubiquitination. PLoS One. 9(7):e101469. ACE2 DAPI TMPRSS2 DAPI 图5. 16HBE细胞表达ACE-2和TMPRSS2。从左至右:用气液界面(ALI)技术培养的16HBE14o-细胞8天显示血管紧张素转换酶2 (ACE2)和丝氨酸蛋白酶TMPRSS2的表达,它们在新冠病毒(SARS-CoV, COVID-19)感染和病毒复制中发挥重要

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    Sino Biological 新冠病毒Spike重组蛋白 His标签 新冠S蛋白
    ¥4500 - 37830