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- 2025年07月13日
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文献和实验IP3受体是一种内质网通道蛋白, 由四个相对分子质量为260kDa的糖蛋白组成的四聚体。四个亚基组成一个跨膜的通道, 每个亚基都有IP3结合的部位, 当3～4个部位被IP3占据时, 受体复合物构象发生改变, 打开离子通道, 储藏在内质网中的Ca2 随即释放,进入胞质溶胶。
Aspects of CNS Lupus: Mouse Models of Anti-NMDA Receptor Antibody Mediated Reactivity
This chapter describes methods utilized in establishing a mouse model of neuropsychiatric lupus encompassing both cognitive and emotional dysfunction, and a model of the influence of maternal antibody on the developing brain. The antibody
Single-Cell Imaging Techniques for the Real-Time Detection of IP3 in Live Cells
Inositol 1,4,5-trisphosphate (IP3 ) is a ubiquitous second messenger, derived from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2 ) by enzymes of the phospholipase C (PLC) family. Binding of IP3 to its cognate receptor
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