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文献和实验Regulation of Dopamine Transporter Expression by Neuronal Activity
Actions of extracellular dopamine released in the central nervous system are primarily terminated by the dopamine transporter. This protein is also a target for therapeutic and abused psychostimulant drugs. Different methods used to study
alleles (homozygote). This procedure has been used to generate animals lacking either the plasma membrane dopamine transporter (DAT; Fig. 2 ) or the vesicular monoamine transporter (VMAT2; Fig. 3 ). Both DAT and VMAT2 are essential for dopamine homeostasis
Transporter Current Measurements
Na+ /K+ pump, Na+ /Ca2+ exchanger, glutamate transporter and other transporters for dopamine, norepinephrine, GABA, and others, are all electrogenic. These transporters or exchanger transport Na+ ions, with or without transmitters
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